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Reported biochemical potency against human NNMT is in the low-micromolar range with cellular EC₅₀ values in the low-micromolar range for suppression of 1-MNA and lipogenesis, with selectivity over related methyltransferases and NAD⁺-salvage enzymes [1,6,7]
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Overview 5-Amino-1MQ is classified as a potent and selective NNMT inhibitor that appears to preserve both S-adenosylmethionine (SAM) and nicotinamide, potentially enhancing NAD+ availability and cellular energetics
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