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A study on rats with intracerebral hemorrhage (ICH) revealed that GHK pretreatment significantly improved neurological deficits, reduced brain water content, and inhibited neuronal apoptosis
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The hypoxic state not only directly reduces the activity of certain drugs, but also activates the expression of a series of genes related to drug resistance by inducing upregulation of hypoxia-inducible factor (HIF) (Hapke and Haake, 2020)
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