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Loop diuretics* include: • furosemide ( such as Lasix, Diuride, Frudix, Frusemide, Frusedale, Flusapex, Salix, Puresis, Libeo) • torasemide (Isemid, Torsemide, Demadex, Tormis, UpCard) • bumetanide * Loop diuretics are pyridine-3-sulfonurea drugs that act on the thick portion of the nephron's ascending loop of Henle (the part of a kidney tubule that forms a long loop in the medulla of the kidney, from which water and salts are resorbed into the blood), where they inhibit the sodium-potassium-chloride (Na+-K+-2Cl-) cotransporter, leaving sodium (and other ions) to be lost, with water, in the urine

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In practice, patients with AP are typically admitted after the onset of significant symptoms, at which time the optimal opportunity for early intervention is often missed