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Recent Advances in Folates and Autoantibodies against Folate Receptors in Early Pregnancy and Miscarriage

Leigh IM, Navsaria H, Purkis PE, McKay IA, Bowden PE, Riddle PN

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Mechanistically, inhibition of PDI’s catalytic activity by catechol estrogens abrogates erastin/RSL3-induced dimerization of nitric oxide synthase, thereby preventing the subsequent accumulation of cellular nitric oxide, ROS and lipid-ROS, and ultimately ferroptotic cell death

Its main role is to turn fat into energy by assisting in the transport of fatty acids into the mitochondria