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While Aβ depositions and tau accumulation are the major hallmarks of AD, abnormalities in cerebral glucose metabolism in specific brain areas forecast the diagnosis of AD based on histopathological changes and can even be correlated with the disease progression [44, 45]
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Moreover, some metallodrugs undergo redox cycling, in which metals like copper, iron, or manganese oscillate between oxidation states, continuously generating ROS (Zhao et al., 2023)
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