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Intriguingly, spread of pαSYN from the periphery to the brain is observed, accompanied by motor deficits (218, 219)
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2.2 The role of immune checkpoint molecules TIGIT and PD-1 in Tregs exhaustion TIGIT (T cell immunoreceptor with immunoglobulin and ITIM domains) and PD-1 (programmed cell death protein 1) are inhibitory receptors prominently expressed on Tregs, playing critical roles in modulating their immunosuppressive functions
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