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“You start at a high temperature, then a medium temperature, and go to a low temperature.” But for something driven out of equilibrium, “it’s not really true to say that the system has a temperature,” and “since that’s the case you can have strange shortcuts.” The thought-provoking work drew the interest of others, including a Spanish group that began simulating what are known as granular fluids — collections of rigid particles that can flow like liquids, such as sand or seeds — and showed that these, too, can have Mpemba-like effects

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143 A mitochondria-targeting nanoplatform was recently developed by conjugating folic acid-modified MCNs with the bioactive peptide M27-39, achieving dual therapeutic effects against both colorectal cancer and IBD