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By using the Cytoscape tool, 14 core targets, namely, PTGS2, EGFR, HIF1A, cyclin-dependent kinase inhibitor 2A (CDKN2A), vascular endothelial growth factor A (VEGFA), interferon gamma (IFNG), dual specificity phosphatase 1 (DUSP1), NADPH oxidase 4 (NOX4), solute carrier family 3 member 2 (SLC3A2), solute carrier family 2 member 1 (SLC2A1), caveolin 1 (CAV1), carbonic anhydrase 9 (CA9), transferrin receptor (TFRC), and DNA damage-inducible transcript 4 (DDIT4) were obtained
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Preconditioning of the myocardium by electrically induced tachycardia increases the activity of the ryanodine receptor 2 (RyR2), a channel that controls the flow of Ca 2+ out of the sarcoplasmic reticulum in cardiac muscle [151]
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