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Abbreviations Supplementary Materials The following supporting information can be downloaded at: Table S1: Changes in gene expression and circadian cycling of gene expression in young and aged liver for mice on ad libitum and 5 different isocaloric DR diets, where the feeding times were altered over the circadian cycle, for over 300 select genes involved in NADPH and lipid metabolism and that could potentially play a role in DR-mediated longevity

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Combines NAD⁺, glutathione, and selected B vitamins to boost mitochondrial energy production