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FDA Issues Five Warning Letters to Makers of Knockoff GLP-1 Drugs | FIDJ

By use of GRK overexpression and knockdown methods in HEK293 cells, the same group recently reported DAMGO-induced phosphorylation of Thr370 and Ser375 is catalyzed by GRK2 and GRK3, but morphine-induced phosphorylation of Ser375 is predominantly mediated by GRK5 (Doll et al., 2012)

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This provided the impetus for more clinical trials for gene therapy to obtain a better understanding of factors underlying the success of the therapy