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The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI | Nature Communications
Its inability to be synthesised endogenously by humans, coupled with the existence of a dedicated cellular transporter, elevates its status to that of a “conditionally essential nutrient” or “longevity vitamin,” making dietary acquisition a must
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Scope and Focus of the Review This review synthesizes recent preclinical and clinical literature on Zn deficiency and its association with adverse inflammatory heart conditions to determine whether Zn supplementation may serve as an accessible, safe intervention against these potentially lethal cardiovascular conditions
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