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Importantly, this imbalance may arise from either increased ROS generation (i.e., via iron) and/or depletion of antioxidant defence (by glutathione depletion), with the latter given less weight in terms of being a cause of ferroptosis in diseases such as Alzheimer’s and Parkinson’s where iron elevation is a signature (Figure 1)

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No differences in serum selenium levels and blood glutathione peroxidase activities in patients with vitiligo compared with healthy control subjects