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In addition to its prooxidant activity leading to GSH depletion [86], chloroquine accumulates into lysosomes leading to their alkalinization and to the impaired uptake of many nutrients from the blood, including transferrin-bound iron
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Endogenous peroxidase was blocked with 3% hydrogen peroxide, and non-specific binding was prevented with Protein Block (TA-125-PBQ, Thermo Fisher Scientific, USA)
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