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[2] Dose Titration Strategies Starting with doses at the lower end of the therapeutic range (0.5-1.0 mg/kg) and increasing by 0.25-0.5 mg/kg weekly intervals reduces initial side effect burden by approximately 40-50%
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Targeted inactivation of the insulin receptor gene in mouse 3T3-L1 fibroblasts via homologous recombination
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