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Sigma, Saint Louis, Missouri) Oxidative stress was assessed by the quantification of protein carbonyls and MDA using Protein Carbonyl Colorimetric and TBARS Assay Kits, respectively (Cayman Chemical, Ann Arbor, MI)
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The verified data notes that spironolactone at 25 mg/day reduced average daily weight fluctuation due to water retention from 2.3 kg to 0.8 kg in clinical trials of women with menopause related fluid imbalance, which supports the role of aldosterone mediated sodium retention in this process
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