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However, when these antioxidant systems become insufficient, oxidative stress products accumulate in the body and contribute to the development and progression of several inflammatory disorders, as it has been observed in Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, multiple sclerosis, hereditary spastic paraplegia, and COVID-19 , (Figure )

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As an important component of pain processing, targeting interleukin-6 could be a promising lead to novel therapeutic strategies for pathological pain (Zhou et al., 2016a)