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Vintage 1953 RUBRAMIN Vitamin B12 vial medicine for the treatment of Anemia. E.R. SQUIBB & SONS – New York Stock Photo - Alamy
Introduction Proton pump inhibitors (PPIs) are currently the most widely used acid-suppressive agents and are the first-line therapy for gastric acid–related disorders, such as peptic ulcer disease, gastroesophageal reflux disease (GERD), and Barrett’s esophagus ( + , K + –ATPase activity in epithelial cells to prevent gastric acid secretion (Sachs et al., 2006
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None of this was replicated in a controlled trial, and the reported response rates come from small unblinded series
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