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Pharmacological Effects of Humic Substances and Their Signaling Mechanisms

135 Our experiments in rats with Ang IV and with more selective ‘AT 4 -ligands’, LVV-H7 and AT4–16, did not reveal any putative AT 4 /IRAP-mediated vasodilator response neither after systemic nor after renal administration, and also not after AT 1 receptor blockade

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But the investigators noted major differences in the effect of vitamin C between the trials, with the greatest benefit observed among patients who were on mechanical ventilation for the longest duration – the patients who were most critical