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Joint and bone-related autoimmune diseases In immune-mediated arthritides such as rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA), the inflammatory microenvironment is orchestrated not only by T cells and macrophages but also by fibroblast-like synoviocytes (FLS), chondrocytes, and osteoclasts
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however, a major challenge for the future is to fully identify appropriate niche signals instructive for organ formation, differentiation, and maintenance
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