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Wild-type C57BL/6 mice, After a week of intraperitoneal injection with the CD38 inhibitor 1 (compound 78c) at a dose of 15 mg/kg every 2 days, a single intraperitoneal (i.p.) injection of LPS was administered 24 h after the last dose

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Summary and Conclusion After the discovery of NAC as effective antidote against APAP hepatotoxicity almost 50 years ago, little progress was made to advance any of the numerous agents that showed protection in various animal or cell models to the clinic