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Additionally, a study of 550,000 patients in China found that emissions from industrial waste gas (consisting mainly of particulate matter, sulfur dioxide, and nitrogen dioxide) were associated with increased thyroid cancer ( A further study demonstrated that the probability of developing papillary thyroid cancer increased with a longer duration of PM 2.5 exposure: a 5 μg/m 3 increase of PM 2.5 concentrations over 12 months of exposure was not associated with the incidence of PTC, but the odds of developing PTC after a 5-μg/m3 increase in PM 2.5 exposure was increased by 18% in 24-month and by 23% after 36-months of exposure ( Heavy metals are considered among known carcinogenic environmental pollutants

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and performing natural history studies in diverse ALS populations, which may be able to serve as controls for future trials [317]