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Each stacked unit was composed of two cis -dimers and two allo -dimers, forming an octameric assembly that extended into filaments through interactions mediated by the oligomerization loop ( Figure 5D )
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CYP2E1 generates large amounts of ROS that can damage cellular and mitochondrial components, such as mitochondrial DNA and cytochrome c oxidase, enhancing local and cellular oxidative stress [72]
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