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Kunz M, Gama CS, Andreazza AC, Salvador M, Cereser KM, Gomes FA et al
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This elevated HPA output in MDD is thought to be mediated by reduced glucocorticoid-mediated negative feedback, an idea which stems from findings that oral administration of synthetic glucocorticoids fails to reduce cortisol secretion in patients with MDD, whereas the same treatment results in robust suppression of cortisol in healthy individuals [134
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