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Secondary validation showed that subsets of B-cell acute lymphoblastic leukemia (B-ALL) cell lines, namely 697, NALM6, HAL01, REH and primary patient B-ALL samples were sensitive to ferroptosis induction by volasertib

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A key aspect of mitochondrial signaling is the generation of mtROS, which function as crucial second messengers in both adaptive and innate immune regulation, participating in the M1/M2 polarization of macrophages and determining the type and intensity of the immune response (89)