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Remarkably, despite increased liver non-heme iron levels in mice with Gpx4 -deficient hematopoietic cells, hepatic hepcidin mRNA expression was not affected, regardless whether mice were kept on a normal or on a vitamin E-depleted diet (Figure 6H)

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To corroborate this hypothesis, several studies evaluated the levels of MDA in serum and scalp tissues of patients with AA, highlighting higher levels of MDA compared to controls [94,95] and a correlation between disease duration and severity with MDA levels [96]