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Of the fifteen tetrazole-hydrazone hybrids designed and synthesized, compound 4 (2-[(1-(4-Hydroxyphenyl)-1H-tetrazol-5-yl)thio]-N'-(4-fluorobenzylidene) acetohydrazide) exhibited strongest AR inhibitory activity comparable to epalrestat without cytotoxicity to normal NIH/3T3 cells [168]
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