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Increased activation of the nucleotide-binding oligomerization domain-like receptors containing pyrin domain 3 (NLRP3) inflammasome has been linked to the development of various conditions, such as atherosclerosis, MASLD, T2DM, and numerous others [39]
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when addressing systemic effects, it primarily refers to overall glucose regulation, as indicated by indices such as the Waist-to-Triacylglycerol Index (WTI), triglyceride-glucose index (TyG index), and metabolic score for insulin resistance (METS-IR)
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