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F 2 -iPs are elevated in AD brain regions rich in the typical lesions such as frontal/temporal cortex and hippocampus but not in cerebellum, an area typically lacking senile plaques or NFT (293, 294)
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Some community members are running this sequence deliberately: start with NAD+ precursors (NMN/NR) to raise the baseline pool, then add MOTS-C to put that pool to work, then layer in 5-Amino-1MQ to block the pathway that drains it
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