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Persistent depletion of OPCs in the subcortical white matter tracts was shown after MTX treatment both in humans and mice (Gibson et al., 2019)

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The pigs did not develop significant clinical signs upon FMDV challenge, while a potent anti-FMDV immunoglobulin A response (local and systemic) was observed, despite the parenteral administration of the peptide, which constitute MAPs dendrimers as promising vaccine candidates