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A 2021 review in Nature Reviews Molecular Cell Biology describes a gradual drop in tissue and cellular NAD+ across aging in rodents and humans, and links that fall to metabolic disease, cognitive decline, and sarcopenia [1]

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Claimants must also provide evidence that they have “marked” limitations in two, or “extreme” limitations in one, of the following areas of mental functioning: understanding, remembering, and applying information (such as learning new things, exercising judgment, planning, and following instructions) interacting with others in socially appropriate ways being able to focus on tasks long enough to complete them in a reasonable time, and adapting or managing oneself (such as regulating emotions, handling changes in routine, taking precautions around danger, and dressing appropriately at work.) Extreme limitations are more severe than marked limitations