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This bell-shape pharmacology of H 2 S may, at least in part, explain the inconsistent results of the effect of exogenous H 2 S in colon cancer cell line HCT116 reported by different groups including a growth inhibitory effect (using NaHS at 400 μ M and 800 μ M) by the Deng lab [66] and a growth stimulatory effect (using NaHS at 30-300 μ M) by the Szabo lab [49, 65, 67]

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MOTS-C MOTS-C activates AMPK, improving cellular energy efficiency, glucose uptake, and fatty-acid oxidation