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The Blood–Brain Barrier, Oxidative Stress, and Insulin Resistance

Beyond its role in the intestinal degradation of histamine in humans, DAO is also present in microorganisms, plants and animals, where it also catalyzes the oxidative deamination of the primary amino group of histamine into its corresponding aldehyde, concomitantly producing stoichiometric amounts of ammonia and hydrogen peroxide (Figure 4) [14,59,60]

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Erastin induces ferroptosis by inhibiting cystine uptake through system Xc− and weakening antioxidant defenses, while GPX4 inhibition or depletion causes lipid peroxide accumulation and ferroptotic cancer-cell death