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“Our position is that FDA has a job, which is to do the science on these kinds of issues and then tell the public what they’ve learned from the science,” he said

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First, at the mechanistic level, single-cell spatial transcriptomics and metabolomics should be used to map ferroptosis pathways in nigral dopaminergic neurons, astrocytes, and microglia, with emphasis on the interplay between NCOA4-mediated ferritinophagy and α-synuclein degradation, to build a dynamic model linking iron dysregulation, proteotoxic stress, and cell death