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Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines - PMC

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In controlled human malaria infection (CHMI) experiments, a sustained increase in circulating G-MDSC was found in volunteers who developed Plasmodium falciparum parasitemia, which suppressed the proliferation of CD4 + and CD8 + T cells and led to a decrease of lymphocytes, interfering with the production of immune memory against the parasite and suppressing the body’s immune response (256)