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Additionally, genetic factors, including mutations in APP, presenilin 1 (PSEN1), and presenilin 2 (PSEN2), as well as the ε4 allele of apolipoprotein E (APOE4), increase the risk of AD by influencing amyloid and tau pathology (Karran and De Strooper 2016 )
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( 10.1021/acs.chemrev.5b00620) [DOI] [PubMed] [Google Scholar] 16.Kuila T, Bose S, Mishra AK, Khanra P, Lee JH
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