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Antibodies having an increased half-life in vivo can also be generated introducing one or more amino acid modifications (i.e., substitutions, insertions or deletions) into an IgG constant domain, or FcRn binding fragment thereof (preferably a Fc or hinge-Fc domain fragment)

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Numerous studies have revealed that markers in the oxidative circulation are higher than normal in PCOS patients and that oxidative stress plays a role in the development of PCOS (90)