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GSH is exclusively degraded at the extracellular level by cells expressing γ-glutamyltranspeptidase (GGT), such as those of the hepatobiliary tree and of other organs like the heart, kidney, lungs, pancreas, and seminal vesicles
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43 Several studies reported that Nrf2 and its transcriptional activity decline with increasing COPD severity 44-46 allowing for the hypothesis that sulforaphane may decrease oxidative stress and inflammation in COPD patients
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