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In addition, in order to compare PRP in terms of effectiveness and suitability for your particular situation, you'll need to acquaint yourself with how prolotherapy works too.If you have suffered an injury or need relief from a painful condition like arthritis, here is a short summary of how PRP and prolotherapy work, what they're typically used for, and how they do what they do.What Is Prolotherapy and How Does It Work?Prolotherapy is a popular and widely "recognized orthopedic procedure" that both repairs and strengthens joints and all forms of connective tissue after they have become injured or are in a state of pain.Prolotherapy got its name from the longer form of the term, "proliferative therapy." It is a routine non-surgical approach that is similar, in many ways, to PRP