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Discussion There were two key findings in this study of older HIV-infected patients: 1) deficient intracellular GSH synthesis and decreased GSH regeneration contribute GSH deficiency and can be corrected with short-term cysteine plus glycine supplementation and 2) correcting GSH deficiency was associated with marked improvements in mitochondrial fuel oxidation in the fasted and fed states, insulin sensitivity, muscle strength, and body composition

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5.3 The challenge of clinical translation 5.3.1 Lack of large-scale randomized controlled trials (RCTs) The potential of functional food active ingredients in combating conditions such as cancer has received widespread attention at the in vitro and animal levels, but high-quality human evidence is relatively scarce