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Comparative experiment of the HL-60 cell differentiation induction and growth-promoting activity in vitro of the glutathione derivative - 2 In a manner similar to that in Example 20, the in vitro activity of the glutathione derivatives of Examples 4, 5, and 8, and Comparative Example 3 were compared

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Therapeutic intervention involved selenium supplementation (200 μg daily selenomethionine), which reduced anti-TPO titers by 60% over 12 weeks through enhanced glutathione peroxidase activity, protecting thyrocytes from oxidative damage, combined with omega-3 fatty acids (2g EPA/DHA daily) that reduced IL-17A levels by 45% through peroxisome proliferator-activated receptor-gamma activation, inhibiting NF-κB-mediated inflammatory gene transcription