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Exclusion criteria: (1) Patients with abnormal coagulation function [limits: prothrombin time (PT) between 10–14 seconds, activated partial thromboplastin time (APTT) between 25–40 seconds, and fibrinogen (Fib) levels between 2.0–4.0 g/L] and immunodeficiency [either primary immunodeficiency (congenital or hereditary conditions leading to impaired immune responses) or secondary immunodeficiency (conditions acquired through HIV infection, chronic immunosuppressive therapy, or severe malnutrition)]

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This strict protocol is critical because globally, 10-15% of untreated cases lead to neuropathy within just six months