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Similarly, HGC was found to be linked with the chemical drug (Kim et al., 2006), optical imaging agent, and magnetic resonance imaging (MRI) contrast agent (Key et al., 2012) for various uses, and MHI-148 can also be incorporated with nanoparticles carrying the MRI contrast agent for NIR and MRI due to the characteristics of optical imaging and tumor targetability (Thomas et al., 2018)