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72 Previous Study has shown that SAH can reduce the expression of DNA methyltransferase DNMT1 protein, lead to demethylation of the CpG islands in the NF-κB gene promoter region, and increase NF-κB expression, trigger the expression of pro-inflammatory senescence-associated secretory phenotype (SASP) factors, and thus induce cellular senescence in rat aortic smooth muscle cells
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