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Detailed characterization of pro-tumor or antitumor effects of NNMT may pave the way for the development of inhibitors and treatment in tumor patients with high or low NNMT expression
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It would take an adequately powered randomized controlled trial that genotypes participants at the relevant loci, randomly assigns them to different B12 forms, and measures functional outcomes such as holotranscobalamin, methylmalonic acid, and homocysteine over time, testing for a genotype-by-form interaction
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