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A Phase 1/1b Study of IAM1363, a selective and brain penetrant HER2 inhibitor in participants (pts) with advanced cancers harboring HER2 alterations
The mTOR pathway, serving as a critical metabolic regulator and mitophagy gatekeeper, integrates both metabolic and inflammatory signals to calibrate mitochondrial turnover and ROS production—key mediators of ferroptosis induction by Erastin (63–65)
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Boyut:5 Kilogram (11 Lbs)
[DOI] [PubMed] [Google Scholar] 130.Freedman JH, Ciriolo MR, Peisach J
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