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announced on 27 February 2026 that approximately 14 of the 19 Category 2 peptides — including semax and selank — would be moved to Category 1

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The substrate binding by the SBD is implemented in two steps: after binding to the client protein via SBD-ß, HSP70s trap it by closing SBD-α, serving as a cap or lid (Wang et al., 1998