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Principal component analysis was performed using normalized transcript counts from three independent biological replicates per condition (R1–R3)

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Shellfish Beans and pulses – chickpeas, soy beans, peanuts Nuts – walnuts, cashew nuts Chocolates and other cocoa based products Vinegar Ready meals Salty snacks, sweets with preservatives and artificial colorings Low Histamine Foods Fresh meat (cooled, frozen or fresh) Freshly caught fish Chicken (skinned and fresh) Egg yolk Fresh fruits – with the exception of strawberries, most fresh fruits are considered to have a low histamine level (also see histamine liberators below) Fresh vegetables – with the exception of tomatoes Grains – rice noodles, yeast free rye bread, rice crisp bread, oats, puffed rice crackers, millet flour, pasta (spelt and corn based) Fresh pasteurised milk and milk products Milk substitutes – coconut milk, rice milk Cream cheese, butter (without the histamine generating rancidity) Most cooking oils – check suitability before use Most leafy herbs – check suitability before use Most non-citric fruit juices Some Herbal teas Diagnosing Histamine Intolerance Histamine intolerance, as previously noted, is difficult to diagnose