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GHK-Cu and Gene Expression Research Research using the Broad Institute’s Connectivity Map found that GHK is capable of up- and downregulating at least 4,000 human genes, with studies identifying 47 DNA repair genes stimulated and 5 suppressed — findings that suggest a broad regulatory role at the genomic level
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Abbreviations AA: Arachidonic acid ALA: α-Linolenic acid COX: Cyclooxygenase CYP: Cytochrome P450 DHA: Docosahexaenoic acid EPA: Eicosapentaenoic acid CYPe: Cytochrome P450 epoxygenase CYPh: Cytochrome P450 hydroxylase DiHDPE: Dihydroxy-docosapentaenoic acid DiHETrE: Dihydroxy-eicosatrienoic acid DiHOME: Dihydroxy-octadecenoic acid EPA: Eicosapentaenoic acid EpETrE: Epoxy-eicosatrienoic acid EpOME: Epoxy-octadecenoic acid GLA: Gamma-linolenic acid HDoHE: Hydroxy-docosahexaenoic acid HEPE: Hydroxy-eicosapentaenoic acid HETE: Hydroxy-eicosatetraenoic acid HETrE: Hydroxy-eicosatrienoic acid HHTrE: Hydroxy-heptadecatrienoic acid HODE: Hydroxy-octadecadienoic acid HOTrE: Hydroxy-octadecatrienoic acid LA: Linoleic acid LOX: Lipoxygenase mEH: Microsomal epoxide hydrolase sEH: Soluble epoxide hydrolase References Gunaydin, C
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