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In addition, reduced glutamate release in the dorsal hippocampus has been linked to spatial memory loss

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Further experiments showed that once in contact with neurons, streptolysin S prompts them to dispatch a pain signal to the brain, alerting it that something is wrong, while at the same time inducing them to release a nerve chemical, the neurotransmitter calcitonin gene-related peptide (CGRP), to keep the immune system at bay