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Frontiers | Glutamine metabolism in cancers: Targeting the oxidative homeostasis

With the induction of inflammation, there is an augmentation in Il-6 production, which would constitute a pro-survival signal in GBM (Van Meir et al., 1990) and particularly in GSCs, which preferentially express the IL-6 receptor alpha (IL-6Rα) and glycoprotein 130 (gp-130), generating the heterodimerization of receptors and culminating in the activation of stat-3 signaling (Wang et al., 2009)

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